Akbar Karkhaneh

Get full access to this article View all access and purchase options for this article. References 1. Saghazadeh S, Rinoldi C, Schot M, et al. Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev 2018; 127: 138–166, Available from: https://linkinghub.elsevier.com/retrieve/pii/S0169409X18300607 2. Anderson K, Hamm RL. Factors that impair wound healing. J Am Coll Clin Wound Spec 2012; 4(4): 84–91. 3. Plichta JK, Gao X, Lin H, et al.

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Abstract Although essential nanosystems such as nanoparticles and nanocarriers are desirable options for transporting various drug molecules into the biological environment, they rapidly remove from the circulatory system due to their interaction with multiple in vivo barriers, especially the immune barrier, which will result in their short-term effects.