Akbar Shakoor

Keywords Aged, Aged, 80 and over, Cell Nucleus, Female, Frozen Sections, Gene Expression Profiling, Healthy Volunteers, Humans, Male, Photoreceptor Cells, RNA-Seq, Single-Cell Analysis, Bioinformatics, Gene expression analysis, Genetics, Gene expression, Sequencing Abstract Single-cell RNA-seq is a powerful tool in decoding the heterogeneity in complex tissues by generating transcriptomic profiles of the individual cell.

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

New Results doi: https://doi.org/10.1101/2022.12.19.521092 Abstract Age-related macular degeneration (AMD) is a complex neurodegenerative disease and is the leading cause of blindness in the aging population. Early AMD is characterized by drusen in the macula and causes minimal changes in visual function. The later stages are responsible for the majority of visual impairment and blindness and can be either manifest as geographic atrophy (dry) or neovascular disease (wet).