Akhinur Rahman

The first two authors contributed equally to this article. Tomoya, RigelSuzuki, AkhinurRahman, et al. 2026. “Analysis of HBV Genome Integration in Patients With HBV-Previously Infected NBNC-HCC,” Hepatology Research: 1–13. Saito, https://doi.org/10.1111/hepr.70163. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The BAM files analyzed from all patient samples have been deposited at NCBI BioProject (accession: PRJNA1185153).

1 Introduction Oral cancer accounts for approximately 50% of head and neck cancers, with over 90% of oral cancers being oral squamous cell carcinoma (OSCC). Common sites of occurrence include the tongue, upper and lower gingiva, buccal mucosa, floor of the mouth, hard palate, and lips. Despite advancements in diagnosis and treatment in recent years, the survival rate of OSCC patients has not significantly improved over the past 30 years.

Abstract Background: The incidence of non-B non-C hepatocellular carcinoma (NBNC-HCC), which is negative for hepatitis B surface antigen and hepatitis C virus antibodies, is on the rise. Relatively high numbers of NBNC-HCC patients are hepatitis B core antibody (HBcAb) positive, suggesting that previous HBV infection may play a role in NBNC-HCC development, though the exact mechanisms are unclear.