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Akmal Salimov

As seen in: Nature
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Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response | Leukemia

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By Sarah J Skuli, Roberta Buono, Francesca Liccardo, Eva Nee, Kara N. Maxwell, Jean-Emmanuel Sarry, David A Fruman, Angelo D’Alessandro, Pamela Sung, Robert L. Bowman, Akmal Salimov
| Nature Verified
Abstract Acute myeloid leukemia with mutations in TP53 (TP53mut AML) is fatal with a median survival of 6 months. RNA sequencing on purified AML patient samples showed that TP53mut AML had higher expression of mevalonate pathway genes.
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