Akshaya L. Krishnamoorthy on Muck Rack

Akshaya L. Krishnamoorthy

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Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities

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By Mariette Kranendonk, Julie Lammers, Raoull Hoogendijk, Akshaya L. Krishnamoorthy
| biorxiv.org
Abstract Background: Pediatric-type diffuse high-grade gliomas (pHGG) are a leading cause of pediatric cancer-related mortality. Although immunotherapy offers a promising treatment avenue, clinical responses in pHGG patients remain limited. A detailed understanding of the tumor immune microenvironment (TIME) is essential for advancing immunotherapeutic strategies.
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