Akshaya Ramakrishnan on Muck Rack

Akshaya Ramakrishnan

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Articles

epiAneufinder identifies copy number alterations from single-cell ATAC-seq data - Nature Communications

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By Akshaya Ramakrishnan, Aikaterini Symeonidi, Katharina Schmid, Maria Richter, Michael Schubert
| Nature Verified
Abstract Single-cell open chromatin profiling via scATAC-seq has become a mainstream measurement of open chromatin in single-cells. Here we present epiAneufinder, an algorithm that exploits the read count information from scATAC-seq data to extract genome-wide copy number alterations (CNAs) for individual cells, allowing the study of CNA heterogeneity present in a sample at the single-cell level.
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epiAneufinder: identifying copy number variations from single-cell ATAC-seq data

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By Aikaterini Symeonidi, Michael Schubert, Akshaya Ramakrishnan, Patrick Hanel
| biorxiv.org
Abstract Single-cell open chromatin profiling via the single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) assay has become a mainstream measurement of open chromatin in single-cells. Here we present a novel algorithm, epiAneufinder, that exploits the read count information from scATAC-seq data to extract genome-wide copy number variations (CNVs) for individual cells, allowing to explore the CNV heterogeneity present in a sample at the single-cell level.
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