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Akshey Suresh

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Articles

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

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By Xia Ding, Divya Swaminathan, Suhas S. Kharat, Akshey Suresh
| Science Magazine Verified
TET2 and 5hmC mark the forks for APE1 Inhibitors of the enzyme PARP, commonly used to treat various tumors, block the repair and restart of stalled replication forks, which eventually kills cancer cells. Kharat et al. found that the DNA demethylase TET2—which is associated with epigenetic control of transcription—was critical for sensitivity to PARP inhibitors by promoting repair-mediated degradation of stalled forks.
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