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Articles by Ala Jo
Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation
Proteolysis-targeting chimeras (PROTACs) have emerged as a promising technology for inducing targeted protein degradation by leveraging the intrinsic ubiquitin-proteasome system (UPS). While the potential druggability of PROTACs toward undruggable proteins has accelerated their rapid development and the wide-range of applications across diverse disease contexts, off-tissue effect and side-effects of PROTACs have recently received attentions to improve their efficacy.
Engineered nanoparticles for clinical assays - Nature Reviews Bioengineering
Abstract Nanoparticles exhibit distinctive physical and chemical properties that make them effective mediators for optical, magnetic or electric signal transduction. Consequently, nanoparticles are increasingly used in the development of biosensing systems that can detect diseases rapidly and accurately, with potential applications extending to point-of-care settings.
A magnetically powered nanomachine with a DNA clutch - Nature Nanotechnology
Abstract Machines found in nature and human-made machines share common components, such as an engine, and an output element, such as a rotor, linked by a clutch. This clutch, as seen in biological structures such as dynein, myosin or bacterial flagellar motors, allows for temporary disengagement of the moving parts from the running engine. However, such sophistication is still challenging to achieve in artificial nanomachines.
Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection (Adv. Sci. 27/2023)
Graphical Abstract Early Cancer Message from the Source Most high-grade serous ovarian cancers originate from the precursor lesions in the fallopian tube. This biological insight offers a novel opportunity to detect early ovarian cancer by assessing circulating extracellular vesicles specific to the fallopian tube. Both preclinical and pilot clinical studies demonstrate a promising perspective for such an approach. More details can be found in article number 2301930 by Cesar M. Castro, Daniela M.
Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection
SAViA Assay We suspended EV isolates in 0.05 m carbonate-bicarbonate buffer (pH 9.4; Millipore Sigma, C3041) and loaded the solution into a high-binding 384-well plate (Greiner, 781 077). Under this pH, proteins tend to be deprotonated and attain high solubility, which improves their adsorption to the plate surface. The sample volume (25 µL per well) was the nominal amount recommended for a 384-well plate.
Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer
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An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma
Abstract Assays for cancer diagnosis via the analysis of biomarkers on circulating extracellular vesicles (EVs) typically have lengthy sample workups, limited throughput or insufficient sensitivity, or do not use clinically validated biomarkers.
Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity
Highlights • Extracellular vesicles (EVs) are heterogeneous in their origins and contents • Expression of CD9 and CD81 are mutually exclusive at the single EV level • Cells shed fewer EVs during the process of immortalization and transformation • tRNA fragments are enriched in ribonucleoprotein complexes Summary Cancer extracellular vesicles (EVs) are highly heterogeneous, which impedes our understanding of their function as intercellular communication agents and biomarkers.
Pyrazolo[1,5-a]pyridine-Fused Pyrimidine Based Novel Fluorophore and Its Bioapplication to Probing Lipid Droplets
A new fluorescent core skeleton containing pyrazolo[1.5-a]pyridine-fused pyrimidine, named Fluoremidine (FM), was discovered. FM analogues were prepared via a one-pot silver-catalyzed cascade cyclization. An N,N-dimethylamino group at the R1- and R2-positions plays important roles in controlling fluorescent brightness and emission wavelength. An N-acetyl group at the R3 position contributes to red shifting of the emission wavelength.
High-content screening platform with fluorescent chemical probes for discovery of first-in-class therapeutics
Phenotypic screening has emerged as a promising approach to discover novel first-in-class therapeutic agents. Rapid advances in phenotypic screening systems facilitate a high-throughput unbiased evaluation of compound libraries. However, limited sets of phenotypic changes are utilized in high-content screening, which require extensive genetic engineering.
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