Alain Bolano Alvarez

Abstract In dermatology, chelates play a significant role in skin care and treatment of skin diseases. Chelates involve coordination bonding between metal ions and organic molecules such as flavonoids. Quercetin (Q) is an extensively studied natural flavonoid with proven safety and anti-inflammatory properties. This study shows the role of two biocompatible metal ions, Iron (Fe2+) and Copper (Cu2+) in coordination bonding with Q in 2-Propanol 50% and 80% at 1:1 stoichiometry.

Abstract We here present a novel and sensitive methodology for determining the melting point (MP) of Bovine Serum Albumin (BSA) from micromolar to picomolar concentration levels under label free conditions. At 1 pM we could model the melting with a sharp gaussian. However, from the transient state observed during the melting process by using a simple exponential decay model we determined a time constant of 67 seconds.

Abstract We here report a study of aggregation of Semaglutide at different temperatures, using resonance light scattering (RLS), fluorescence polarization and back-scattering techniques. Fluorescence emission spectra were obtained by exciting the samples at 275 nm and 295 nm, revealing a peak emission at 600 nm associated with the aggregation process. The size of the aggregates is around 100 nm according to back-scattering measurements.