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First-in-human Phase I study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma

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By Patrick Y Wen, Timothy F. Cloughesy, Alan G Olivero, Kari M Morrissey
| AACR Journal
Research Article Patrick Y. Wen, Timothy F. Cloughesy, Alan G Olivero, Kari M Morrissey, Timothy R Wilson, Xuyang Lu, Lars U. Mueller, Alexandre F Coimbra, Benjamin M Ellingson, Elizabeth Gerstner, Eudocia Q Lee and Jordi Rodon DOI: 10.1158/1078-0432.CCR-19-2808 Abstract Purpose: GDC-0084 is an oral, brain-penetrant small molecule inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR).
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