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Alan Gonzalez-Ibarra on Muck Rack

Alan Gonzalez-Ibarra

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Articles

Heavy water labeling reveals metabolic flexibility of amino acid and polyamine pathways in mammalian cells

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By Katarzyna Socała, Nikola Gapińska, Julio Cesar Torres-Elguera, Marek Tchórzewski, Maria Hatzoglou, Dawid Krokowski, Alan Gonzalez-Ibarra, Missael Arroyo-Negrete, Wioleta Banaszuk-Krupa, Tomasz Sawoszczuk
| Nature Verified
Abstract Amino acid and polyamine metabolism underpins many cellular processes, such as cell growth, stress adaptation, and signaling. However, the usage of specific metabolic pathways is highly context-dependent, and there are many compensatory mechanisms in place for the biosynthesis of amino acids. Here, we establish low-dose heavy water (D₂O) labeling as a tracer to monitor amino acid and polyamine metabolism in mammalian systems.
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