Alanur Tutar on Muck Rack

Alanur Tutar

As seen in: Nature
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Articles

AI-guided CRISPR screening reveals therapeutic targets in psoriasis

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By Chenlin Zhao, Mushaine Shih, Sharif U. Ahmed, Steven Song, Amber Lennon, Julia Mayes, Mengqi Jonathan Fan, Pei-Ying Lo, Jason Perera, andrew kang, Elizabeth Warren, Ryan P. McClure Verified, Ryan Mcclure, Shana O. Kelley, Abdalla Abdrabou, Alanur Tutar
| Nature Verified
Abstract Psoriasis affects over 125 million people globally. Biologics targeting the IL-17/IL-17RA axis are effective but require systemic administration, are costly, and are unsuitable for some patients. Developing topical small-molecule alternatives requires a better understanding of how IL-17 receptor A (IL17RA) is regulated in keratinocytes, the principal effector cells of psoriatic lesions.
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