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Abstract The death and clearance of nurse cells is a consequential milestone in Drosophila melanogaster oogenesis. In preparation for oviposition, the germline-derived nurse cells bequeath to the developing oocyte all their cytoplasmic contents and undergo programmed cell death. The death of the nurse cells is controlled non-autonomously and is precipitated by epithelial follicle cells of somatic origin acquiring a squamous morphology and acidifying the nurse cells externally.
Highlights • Lysosome-associated genes are required in follicle cells for nurse cell death • V-ATPases localize to the plasma membrane of follicle cells to acidify nurse cells • Cathepsin L is released by follicle cells and promotes nurse cell DNA degradation Summary Cell death is a fundamental aspect of development, homeostasis, and disease; yet, our understanding of non-apoptotic forms of cell death is limited.
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