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The assembly of tetrameric human L-lactate dehydrogenase is regulated by ionic strength, β-NADH binding, cyclic peptides, and long-chain dicarboxylates
1 INTRODUCTION Lactate dehydrogenases (LDHs) are stereospecific enzymes whose catalytic action is committed to the reversible reduction of pyruvate to L- or D-lactate (Dennis & Kaplan, 1960; Everse & Kaplan, 1973; Garvie, 1980). Interestingly, the structural and functional properties of LDHs isolated from different prokaryotes can significantly diverge.
Structural basis of Nuclear Factor 1-X DNA recognition provides prototypic insight into the NFI family - Nature Communications
Abstract Nuclear Factor I (NFI) proteins are involved in adenovirus DNA replication and regulate gene transcription, stem cell proliferation, and differentiation. They play key roles in development, cancer, and congenital disorders. Within the NFI family, NFI-X is critical for neural stem cell biology, hematopoiesis, muscle development, muscular dystrophies, and oncogenesis.
Fagopyrins from Buckwheat Flowers: Structural and Stereochemical Characterization Through Combined NMR/CD Spectroscopy and Theoretical Calculations
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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