Alberto Miranda Bedate

Protein interaction motifs are most commonly found in intrinsically disordered regions within proteins (Tompa et al., 2014), as structured regions are less accessible to binding with interacting partners. We therefore hypothesised that ITIM/ITSM sequences locate in disordered regions to allow for interaction with phosphatases and kinases.

Abstract Blocking inhibitory receptors like PD-1 and CTLA-4 has revolutionized cancer treatment in recent years. However, despite major successes in melanoma and lung cancer, the majority of cancer types are not responsive to these immunotherapies. As such, there is an ongoing need for the identification of novel inhibitory receptors as drug targets.