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Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives - Critical Care
As previously noted, the available evidence regarding the use of extracorporeal blood purification therapies is inconclusive. Given the limitations of RCTs in this field, associated with heterogeneity in populations and modes and dosing of blood purification therapies, the future of extracorporeal blood purification in sepsis lies in a move from large-scale randomized trials to tailored and adaptive studies targeting specific and objective patient criteria with standardized therapeutic protocols.
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