Alec Basil Heckert on Muck Rack

Alec Basil Heckert

As seen in: Nature, eLife
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Articles

Oblique line scan illumination enables expansive, accurate and sensitive single-protein measurements in solution and in living cells - Nature Methods

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By Alec Basil Heckert, Markus Seeger, Liam Elliott, Joshua Isaacs, Eugene Park, Stephen Basham, Jaclyn Ho, Xavier Darzacq, Eric Betzig, Russell Berman Verified, Brianna Conroy, Brian Margolin
| Nature Verified
Abstract An ideal tool for the study of cellular biology would enable the measure of molecular activity nondestructively within living cells. Single-molecule localization microscopy (SMLM) techniques, such as single-molecule tracking (SMT), enable in situ measurements in cells but have historically been limited by a necessary tradeoff between spatiotemporal resolution and throughput.
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Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

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By Liza Dahal, Thomas Graham, Gina M. Dailey, Alec Basil Heckert
| eLife
eLife Assessment This important study provides data that challenges the standard model that binding of Type 2 Nuclear Receptors to chromatin is limited by the available pool of their common heterodimerization partner Retinoid X Receptor. The evidence supporting the conclusions is compelling, utilizing state-of-the-art single-molecule microscopy. This work will be of broad interest to cell biologists who wish to determine limiting factors in gene regulatory networks.
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Oblique Line Scan Illumination Enables Expansive, Accurate and Sensitive Single Protein Measurements in Solution and in Living Cells

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By Amine Driouchi, Mason Bretan, Brynmor Davis, Alec Basil Heckert
| biorxiv.org
Abstract Single-molecule localization microscopy (SMLM) techniques, such as single-molecule tracking (SMT), enable in situ measurements in cells from which data-rich metrics can be extracted. SMT has been successfully applied to a variety of biological questions and model systems, aiming to unravel the spatiotemporal regulation of molecular mechanisms that govern protein function, downstream pathway effects, and cellular function.
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