Aleco D’Andrea on Muck Rack

Aleco D’Andrea

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Articles

Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma

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By Micol Ravà, Aleco D’Andrea, Paola Nicoli, Ilaria Gritti
| Science Magazine
Double-hit lymphomas, a type of B cell lymphomas with concurrent activation of the MYC and BCL2 oncogenes, are aggressive and difficult-to-treat tumors. In light of evidence showing that tigecycline, an antibiotic, may be effective against MYC-driven lymphomas, Ravà et al. combined it with venetoclax, a BCL2 inhibitor, to target the double-hit tumors.
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