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Alejandro Díaz-Barreiro on Muck Rack

Alejandro Díaz-Barreiro

As seen in: The Journal of Immunology
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Articles

Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mice and Humans Is Dependent on BLK Expression Levels

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By Ying-Yu Wu, Ina Georg, Alejandro Díaz-Barreiro, Nieves Varela
| The Journal of Immunology Verified
AbstractPolymorphisms in the B lymphoid tyrosine kinase (BLK) gene have been associated with autoimmune diseases, including systemic lupus erythematosus, with risk correlating with reduced expression of BLK. How reduced expression of BLK causes autoimmunity is unknown. Using Blk+/+, Blk+/?, and Blk?/? mice, we show that aged female Blk+/? and Blk?/? mice produced higher anti-dsDNA IgG Abs and developed immune complex–mediated glomerulonephritis, compared with Blk+/+ mice. Starting at young age, Blk+/?
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