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Abstract Adaptive immune receptor repertoire sequencing data has emerged as a promising potential modality for disease diagnosis, relying on computational methods to analyze T-cell receptor (TCR) sequences from an individual's blood sample. Published methods rely on different cohorts, data preprocessing pipelines, and evaluation metrics, making direct comparison across methods challenging.
Abstract To elucidate the genetic architecture of the DNA damage response (DDR) network, we conduct unbiased genetic interaction screens using Cas12a. We disrupt 233 DDR genes frequently mutated in cancer and other genetic diseases, either individually or in pairwise combinations, enabling us to assess the phenotypic effects induced by the loss of DDR gene pairs under unperturbed cell growth conditions.
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