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Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells
1 Introduction Extracellular vesicles (EVs) are small membrane bound vesicles, typically ranging in size from 30 to 200 nm [1], secreted from living cells that can be readily obtained from urine, plasma, or serum [2]. They are increasingly recognized as biomarkers for revealing the pathogenesis of multiple diseases, including neurodegenerative and cardiovascular diseases and cancers [3-8] through minimally invasive liquid biopsy.
Dual-wavelength metalens enables Epi-fluorescence detection from single molecules - Nature Communications
Abstract Single molecule fluorescence spectroscopy is at the heart of molecular biophysics research and the most sensitive biosensing assays. The growing demand for precision medicine and environmental monitoring requires the creation of miniaturized and portable sensing platforms. However, the need for highly sophisticated objective lenses has precluded the development of single molecule detection systems for truly portable devices.
Metasurfaces for Quantitative Biosciences of Molecules, Cells, and Tissues: Sensing and Diagnostics
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Photonics 2024, 11, 3 This article has not yet been cited by other publications.
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