Aleksas Matvekas

Introduction An estimated 25%-30% of drugs are eliminated by the kidneys, necessitating the evaluation of impaired kidney function on the pharmacokinetics (PK) and pharmacodynamics (PD) of investigational agents to inform drug product dose labeling.1 Defining the optimal dose in patients with impaired kidney function is imperative, as close to one billion individuals across the globe suffer from kidney impairment in the forms of chronic kidney disease (CKD) and acute kidney injury (AKI).2, 3...

1 INTRODUCTION Pre-surgery antibiotic prophylaxis is the standard of care and the key to preventing surgical site infection (SSI).1, 2 SSI is the most frequent health care-associated infection in the United States and affects 160,000–300,000 patients each year, especially patients undergoing colorectal surgeries (SSI incidence up to 45%).3-5 The presence of an SSI more than doubles the mean cost of colorectal surgery ($31,933 in patients with infection versus $14,608 in patients without...