Alessandra Tammaro

Abstract Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role in the regulation of longevity. However, identification of universally conserved complex lipid changes that occur during aging, and how these respond to interventions, is lacking. Here, to comprehensively map how complex lipids change during aging, we profiled ten tissues in young versus aged mice using a lipidomics platform.

Abstract Aging increases the risk of developing age-related diseases, which comes at great societal healthcare costs and suffering to individuals. Meanwhile, targeting mechanisms of aging can reduce the risk of developing age-related diseases, resulting in healthy aging. Multiple aging pathways exist, which over past decades have systematically been confirmed through gene knockout or overexpression studies in mammals and the ability to increase healthy lifespan.

Wei Shi, Tian-Tian Wan, Hui-Hua Li* and Shu-Bin Guo* Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Septic acute kidney injury (AKI) is the commonest cause of complication of sepsis in intensive care units, but its pathophysiology remains unclear.