Alessio Bartocci

Introduction Click to copy section linkSection link copied! The sigma-1 receptor (S1R) is a unique transmembrane protein located predominantly in the endoplasmic reticulum (ER) membrane, particularly at the critical mitochondria-associated membrane (MAM) junction, where it orchestrates diverse cellular processes from calcium signaling to protein homeostasis. (1) Its central role in neuroprotection, cancer progression, and pain modulation has positioned S1R as a compelling pharmacological target.

Abstract Visible light photocatalysis, which exploits the reactivity of molecules at their excited state, has triggered a paradigm shift in organic synthesis by enabling some very unique chemical transformations. Yet, achieving precise control of the enantioselectivity in such processes remains a major challenge.

Introduction Click to copy section linkSection link copied! DNA double-strand breaks (DSBs) represent one of the most severe forms of genetic damage, posing a significant threat to genomic stability and cellular health. If left unrepaired or improperly addressed, DSBs can lead to genomic instability, potentially disrupting oncogens and tumor suppressor genes, thereby increasing cancer susceptibility and impacting cancer evolution.