Alex Gardner

Credit: Annushka Ahuja from Pexels Inconsistent use of some GLP-1 weight-loss medications, like Ozempic and Wegovy, may significantly lessen their effectiveness, according to a new preclinical study from researchers at the Perelman School of Medicine at the University of Pennsylvania. The study, published in the Journal of Clinical Investigation Insight, showed that each time overweight mice stopped and restarted GLP-1s, they dropped less and less weight compared to their original weight-loss.

Alex Gardner Cholesterol crystals in the liver may stiffen the organ early in those with metabolic dysfunction-associated steatotic liver disease (MASLD)—well before scarring develops—according to new research from a team in the Perelman School of Medicine at the University of Pennsylvania.

Cryo–scanning electron microscopy (cryo-SEM) micrographs of high-pressure-frozen and freeze-fractured HF (Top) and HFHC (Bottom) livers at 6 wk of diet. HF livers contain liquid lipid droplets (yellow) that either cleave cleanly or leave smooth reliefs across the fractured surface. HFHC livers contain both liquid crystals (orange) and solid crystals (red) in hepatocytes.