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Alex Hewitt

As seen in: Medium, Nature, Wiley, Wiley Online Library, Daily Star (UK), PLOS, Fixing the Future, MDPI, Vanity Fair, JAMA (The Journal of the American Medical Association) and
ophthalmologist; genetics researcher; born when atmospheric CO2 = 337 ppm
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Articles

The impact of sex on the immune system explored at the single-cell level

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By Seyhan Yazar, Jose Alquicira-Hernandez, Kristof Wing, Anne Senabouth, Stacey B. Andersen, Kirsten A. Fairfax, Alex Hewitt, Joseph Powell, Sara Ballouz
| The American Journal of Human Genetics Verified
Keywords sex differences immune cells sex-biased expression expression quantitative trait loci sex chromosomes Introduction Sex differences in the immune system play a critical role in the susceptibility, progression and outcome of autoimmune diseases. These differences are evident in immune parameters such as antigen presentation strength and duration and intensity of immune responses, all of which vary between females and males.
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Opportunistic genomic screening of healthy controls in an Australian biobank

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By Lucas A. Mitchell, Mary-Anne Young, Thomas Ohnesorg, Matthew Hobbs, Alex Hewitt, Joseph Powell, Amanda Willis, Joseph Copty, Jaye S. Brown, Daniel G. Macathur
| Nature Verified
Abstract Leveraging existing genomic data to opportunistically screen for secondary findings (SFs) can identify individuals at increased genetic risk who may be missed by criteria-based testing. While some guidelines support returning actionable SFs with professional support, there is a gap in consistent practice regarding the return process. This study reports the outcomes of opportunistic genomic screening in an Australian biobank.
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Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence

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By Maria Sopena-Rios, Aida Ripoll-Cladellas, Fatemeh Omidi, Sara Ballouz, Jose Alquicira-Hernandez, Roy Oelen, Alex Hewitt, Lude Franke, Monique G. P. van der Wijst, Joseph Powell, Marta Melé
| Nature Verified
Abstract Immunosenescence, the progressive aging of the immune system, is characterized by changes in immune cell composition and function that increase susceptibility to disease. However, how biological sex shapes immune aging at the cellular level remains poorly understood. Here, we analyze single-cell RNA sequencing data from the peripheral blood mononuclear cells of 982 female and male donors across adulthood.
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