Alexa B. D'Angelo

1 INTRODUCTION Sexual minority individuals represent 2−5% of the United States, yet account for more than two-thirds of new HIV acquisitions [1−4]. Meanwhile, gender minority individuals (transgender [trans] men and trans women) accounted for 2% of new HIV acquisitions in 2019, while representing ∼1% of the United States [5−7]. A complex set of factors have hindered our ability to reduce HIV incidence among sexual and gender minority (SGM) individuals who have sex with men.