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Alexa Torrens on Muck Rack

Alexa Torrens

As seen in: New York Daily News, BioRxiv, Cell Metabolism, eLife, The Daily Orange
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Articles

A preclinical model of THC edibles that produces high-dose cannabimimetic responses

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By Anthony English, Fleur Uittenbogaard, Alexa Torrens, Dennis Sarroza
| eLife
eLife assessment This important study presents the validation of an oral Δ9-tetrahydrocannabinol (THC) consumption mouse model utilizing highly palatable e-capsule gelatin. The results convincingly demonstrate that oral consumption produced THC behavioral and physiological effects, as well as measurable brain levels. The utility of the model for chronic consumption remains to be determined. The authors have clearly acknowledged limitations of their model and areas for future study and development.
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A preclinical model of THC edibles that produces high-dose cannabimimetic responses.

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By Anthony English, Alexa Torrens, Dennis Sarroza, Fleur Uittenbogaard
| BioRxiv
Abstract No preclinical experimental approach enables the study of voluntary oral consumption of high-concentration Δ9-tetrahydrocannabinol (THC) and its intoxicating effects, mainly owing to the aversive response of rodents to THC that limits intake. Here we developed a palatable THC formulation and an optimized access paradigm in mice to drive voluntary consumption. THC was formulated in chocolate gelatin (THC-E-gel). Adult male and female mice were allowed ad libitum access for 1 and 2 h.
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Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice

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By Alexa Torrens, Valentina Vozella, of Illinois, Hannah Huff
| Journal of Pharmacology and Experimental Therapeutics
Research ArticleNeuropharmacology Alexa Torrens, Valentina Vozella, Hannah Huff, Brandon McNeil, Faizy Ahmed, Andrea Ghidini, Stephen V Mahler, Marilyn A Huestis, Aditi Das and Daniele Piomelli Journal of Pharmacology and Experimental Therapeutics April 28, 2020, jpet.120.265892; DOI: https://doi.org/10.1124/jpet.120.265892 Abstract We investigated the pharmacokinetic properties of Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive constituent of cannabis, in adolescent and adult male mice.
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