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Alexander Barrett

As seen in: BioRxiv
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Articles

Resiliency to Alzheimer's disease neuropathology can be distinguished from dementia using cortical astrogliosis imaging

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By Stephanie Barsoum, Caitlin Latimer, Amber Nolan, Alexander Barrett
| BioRxiv
Abstract Despite the presence of significant Alzheimer's disease (AD) pathology, characterized by amyloid β (Aβ) plaques and phosphorylated tau (pTau) tangles, some cognitively normal elderly individuals do not inevitably develop dementia. These findings give rise to the notion of cognitive 'resilience', suggesting maintained cognitive function despite the presence of AD neuropathology, highlighting the influence of factors beyond classical pathology.
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An autophagy adaptor TRIAD3A promotes tau fibrillation by phase separation

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By Jiechao Zhou, Javier Redding-Ochoa, Alexander J. Platero, Alexander Barrett
| BioRxiv
Abstract Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report an RBR-type E3 ligase TRIAD3A functions as a novel autophagy adaptor for tau. TRIAD3A(RNF216) is an essential gene with mutations causing age-progressive neurodegeneration. Our studies reveal that TRIAD3A E3 ligase catalyzes a novel mixed K11/K63 polyubiquitin chain and self assembles into liquid-liquid phase separated (LLPS) droplets.
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