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Alexander Bartnik

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning

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By Michael Dwyer Verified, Niels Bergsland, Alexander Bartnik, Dejan Jakimovski, Samantha Noteboom, Menno M Schoonheim, Martijn D. Steenwijk, Jinglan Pei, David Clayton, Robert Zivadinov
| Nature Verified
Abstract Multiple sclerosis (MS) is a chronic neurological disease affecting both white and gray matter of the central nervous system. Despite the well-established involvement of cortical lesions in MS, feasibility limitations in their visualization on typical magnetic resonance imaging (MRI) protocols prevent their evaluation in nearly all clinical trials.
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Determinants of long‐term paramagnetic rim lesion evolution in people with multiple sclerosis

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By Jack Reeves, Alexander Bartnik, Maryam Mohebbi, Murali Ramanathan
| Wiley Online Library Verified
Introduction Chronic active lesions (CALs) are increasingly recognized as an indicator of multiple sclerosis (MS) disease progression.1 CALs exhibit substantial myelin and axonal damage within their core and ongoing axonal deterioration at their periphery, accompanied by iron-rich microglia.2 These lesions can manifest as “paramagnetic rim lesions” (PRLs) on iron-sensitive MRI due to the rim of iron-rich microglia, or on PET scans and longitudinally on T1-weighted and T2-weighted images as...
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MRIO: The Magnetic Resonance Imaging Acquisition and Analysis Ontology

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By MacKenzie Smith, William Duncan, Alexander Bartnik, Lucas M Serra
| BioRxiv
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