Alexander Craig

Environmental Science & Technology Cite this: Environ. Sci. Technol. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

Abstract The KMT2A gene, located at chromosome band 11q23, encodes a lysine methyltransferase essential for hematopoietic gene regulation. While KMT2A rearrangements are common in acute myeloid leukemia (AML) and B-cell acute lymphoblastic leukemia (B-ALL), KMT2A amplification is rare, occurring in ~1% of AML cases and even less frequently in B-ALL. Given its rarity, understanding KMT2A amplification in B-ALL is crucial for improving diagnostics and therapy.

I love many of the Downtown South Bend 2045 Plan’s goals, but there’s a problem: It has goals. Many U.S. cities do need more mixed-use development. They do need small living spaces near jobs and recreation. They do need pedestrian-friendly infrastructure. However, there is a danger in too much planning. Cities are like forests. Forests have no goal. A forest is beautiful because all kinds of unexpected things have an organic place in them.