Alexander EG Viray on Muck Rack

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The Photoswitchable Cannabinoid Azo-HU308 Enables Optical Control of Ca2+ Signaling in Pancreatic β-Cells via a Non CB2 TRPC Channel Mechanism

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By James Frank, Alexander EG Viray
| biorxiv.org
Abstract Ca2+ plays a critical role in regulating insulin secretion from pancreatic β-cells, a process modulated by various cell surface receptors, including cannabinoid receptors (CBRs). However, our understanding of cannabinoid signaling in β-cells is complicated by the intricate pharmacology of cannabinoid ligands and their inherent hydrophobicity, which hinders precise control of receptor activation.
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