Alexander JA Groffen on Muck Rack

Alexander JA Groffen

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Articles

Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

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By Aygul Subkhangulova, Miguel A. Gonzalez-Lozano, August B. Smit, Alexander JA Groffen
| eLife
Editor's evaluation This study examines the function of Tomosyn, in dense core vesicle fusion using CRE-mediated deletion in neuronal cultures from mice expressing conditional alleles of tomosyn and tomosyn-2. Tomosyn is a large soluble SNARE protein, where earlier work in multiple species suggested that it functions as a competitive inhibitor of cognate SNARE interactions impairing fusion.
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