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Alexander Marian Rief on Muck Rack

Alexander Marian Rief

As seen in: BioRxiv
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Articles

Dicer loss in Muller glia leads to a defined sequence of pathological events beginning with cone dysfunction

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By Daniel Larbi, Seoyoung Kang, Shaoheng Chen, Alexander Marian Rief
| BioRxiv
Abstract Purpose: The loss of Dicer in Muller glia (MG) results in severe photoreceptor degeneration as it occurs in retinitis pigmentosa or AMD. However, the sequence of events leading to this severe degenerative state is unknown. The aim of this study was to conduct a chronological functional and structural characterization of the pathological events in MG-specific Dicer-cKO mice in vivo and histologically.
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