Alexander Morin

Abstract Buntanetap is an orally available small RNA targeting molecule that inhibits the translation of multiple neurotoxic aggregating proteins, including amyloid precursor protein (APP) and Tau. It has been evaluated in 13 clinical trials involving over 1000 participants, including healthy volunteers, patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD), and has shown a favorable safety and tolerability profile.

Deep in the forests of modern-day Nigeria and Cameroon, a vibrant ethnic group called the Efiks had a seed that could end a life in minutes. The pod of Physostigma venenosum, better known as the Calabar bean, determined whether a person accused of a crime was innocent or guilty, with innocence decided by survival. Crushed and mixed with water, the potion was given to the accused in this trial by ordeal, and those who vomited it walked free.

Loading metrics Open Access Peer-reviewed Research Article Citation: Morin A, Chu CP, Pavlidis P (2025) Identifying reproducible transcription regulator coexpression patterns with single cell transcriptomics. PLoS Comput Biol 21(4): e1012962. https://doi.org/10.1371/journal.pcbi.1012962 Editor: Chongzhi Zang, University of Virginia, UNITED STATES OF AMERICA Received: November 6, 2024; Accepted: March 13, 2025; Published: April 21, 2025 Copyright: © 2025 Morin et al.