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Articles

Mechanism of spliceosome termination

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By Rupert Faraway, Matthias K. Vorländer, Alexander Phillips, Moritz Wanke, George Yakoub, Gerald Raffl, Laura Fin, Román González-Prieto, Martijn S. Luijsterburg, Stefan L. Ameres, Clemens Plaschka, Vytaute Boreikaite, Leonie Opitz
| Nature Verified
Abstract After excising an intron from pre-mRNA, the spliceosome remains trapped in a non-productive complex bound to the intron1,2,3,4,5. Termination of this complex is critical for spliceosome recycling and intron decay6, but the mechanism remains unknown. Here we present cryo-electron microscopy structures of human spliceosomes at two sequential stages of termination.
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8 Amazing Talks Recommended By Conference Master Herb Kim

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By Alexander Phillips
In a recent interview with Herb Kim, founder of the Thinking Digital conference which takes place every year in Newcastle, England and has been described as the UK’s TED, told us to check out 8 of his favourite talks that you should check out.
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