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Alexandrov LB

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Articles

Combining DNA damaging therapeutics with immunotherapy: more haste, less speed

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By Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR
| Nature Verified
DNA damage arises either due to cellular exposure to exogenous sources of damaging agents such as chemotherapy or because of a failure to repair endogenous DNA damage in cells (Jackson and Bartek, 2009). DNA damage itself can take many different forms depending on the mechanism of action of the agent used (Box 2), with DNA double-strand breaks (DSBs) considered to be the most cytotoxic to cancer cells (Brown et al, 2017).
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