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Alexia Vite

As seen in: Nature, Wiley Online Library, Cell Reports, JACC (Journal of the American College of Cardiology)
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Articles by Alexia Vite

Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes

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By Alexia Vite, Tony Guo, Nesrine Bouhrira, Deborah M. Eaton, Kenneth Bedi, Claire Brady, Jonathan Edwards, Bea Duric, Keita Uchida, Cassidy Olsen, Benjamin L. Prosser, Zoltan Arany, Kenneth B. Margulies, Lola Dong
| Cell Reports Verified
We recently demonstrated that our MRE-based substrate stiffening system induces increased α-tubulin detyrosination in adult cardiomyocytes, a post-translational modification that increases MTN density and stabilization.25 Recognizing that microtubules transport GLUT4-containing endosomes, from the cytosol to the PM in skeletal muscle31,32 and adipocytes,33,34 we next explored the contribution of α-tubulin detyrosination to the formation of GLUT4 aggregates following culture on the stiffened...
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A Dynamic Gradient Stiffness Material Platform to Manipulate Cardiac Fibroblasts' Spatio‐Temporal Behavior

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By Zheng Cao, Biomedical Engineering, Andy Clark, Alexia Vite
| Wiley Online Library Verified
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202402808-sup-0001-SuppMat.pdf473.2 KB Supporting Information References 1, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , et al., Circulation 2019, 139, e56. 2, , , J. Mol. Cell. Cardiol. 2016, 93, 133. 3, , , , Cardiac Fibrosis and Heart Failure—Cause or Effect?, Springer, Berlin, Heidelberg 2015. 4, , , J. Cardiovasc. Pharmacol. 2011, 57, 380. 5, , , , , Circ. Res. 2011, 109, 1120.
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Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes:

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By Alexia Vite, Kenneth Bedi, Emily Flam, Timothy R. Matsuura
| JACC (Journal of the American College of Cardiology)
Introduction The beating heart has a high rate of energy consumption with a very limited capacity to store adenosine triphosphate (ATP). As a result, the myocardium is in constant need of metabolic substrates to generate the ATP required for normal function.1-3 One key adaptation to these challenges is the ability of the heart to utilize a wide variety of metabolic fuel substrates for production of ATP, a feature termed metabolic flexibility.
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Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

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By Christina Chen, Matthew A. Caporizzo, Kenneth Bedi, Alexia Vite
| Nature Verified
Detyrosinated microtubules provide mechanical resistance that can impede the motion of contracting cardiomyocytes. However, the functional effects of microtubule detyrosination in heart failure or in human hearts have not previously been studied. Here, we utilize mass spectrometry and single-myocyte mechanical assays to characterize changes to the cardiomyocyte cytoskeleton and their functional consequences in human heart failure.
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