Cell Reports

The nuclear loss of HMGB2 from normal cells commits them to the fate of senescence, while also triggering 3D genome reorganization.16 Accordingly, we reasoned that ICM treatment will lead to analogous 3D genome changes in PDAC. To test this, we generated 10-kbp resolution Hi-C data from PDO3T treated or not treated with ICM (Table S5).

Results We previously established a clinical workflow for routine collection of needle biopsies from patients with liver cancer during diagnostic procedures, providing a more representative and broadly accessible source of tissue for organoid generation by enabling inclusion of a wider range of patients.13 Building on our previous work, we processed a total of 163 needle biopsies from 122 patients and successfully established tumor organoids in 28 cases, corresponding to a success rate of...

Keywords ESCC acetate H2A.Z acetylation ATM ACSS2 tumor suppression Research topic(s) CP: cancer CP: metabolism Introduction Cancer is a complex disease driven by the coordinated interplay of multiple factors, including genetic alterations, epigenetic reprogramming, metabolic rewiring, and so on.1,2 Deciphering the dynamic crosstalk among these layers is therefore critical, as it not only reveals fundamental oncogenic mechanisms but also opens new avenues for developing precise diagnostic and...

Results To determine whether aboveground herbivory influences parasitoid attraction through plant-soil feedbacks, we established a two-phase experimental system (Figure 1A). During the conditioning phase, cowpea plants were either left uninfested (Control) or subjected to insect herbivory (Herbivory). In the subsequent feedback phase, soil conditioned by these treatments was used to grow new, uninfested cowpea plants, and behavioral responses of parasitoid N. formosa were assessed.

Keywords tuft cell brush cell Trpm5 ATP LTB4 leukotriene, CysLT Pseudomonas aeruginosa mucosal immunity innate immunity Research topic(s) CP: Immunology Introduction Bacterial respiratory tract infections represent a global public health concern. Although pathogen detection by respiratory epithelial cells and the subsequent activation of immune cells are essential for resolving these infections, the underlying mechanisms driving the protective responses remain largely unclear.

Keywords infantile amnesia memory retrosplenial cortex TRAP2 neural circuits brain clearing light sheet fluorescence microscopy fear conditioning Research topic(s) CP: neuroscience Introduction Infantile amnesia describes a process by which episodic memories formed early in life are rapidly forgotten.1,2,3 In contrast, memories formed later can last for decades.

Keywords stress depression adult hippocampal neurogenesis neuronal ensembles resilience helpless behavior Research topic(s) CP: neuroscience Introduction Stressful life events are a prominent risk factor for the onset of episodes of several major psychiatric disorders, particularly major depressive disorder (MDD).1,2,3,4,5,6 Clinical studies suggest that individuals with MDD suffer from defects in adaptive responses to stress7,8 and enhanced memory for negative information,9,10,11 and the...

ArticleOnline now117728Open access Affiliations & Notes 1Institute for Protein Research, The University of Osaka, Osaka, 565-0871, Japan 2RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan 3Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, 160-0016, Japan 4Centre for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, 160-0016, Japan 5Human Technopole, via Rita Levi Montalcini 1, Milan, Italy Article Info...

Building on previous evidence that MNGC formation correlates with prolonged infection duration,23,25 we next sought to investigate the functional role of E-selectin in the formation of MNGC induced by B. pseudomallei. Our results demonstrated that E-selectin was gradually upregulated at 0, 4, 8, and 12 h post-infection (hpi) following B. pseudomallei infection (Figures 2A and 2B). Meanwhile, short hairpin RNAs (shRNAs) were designed to knockdown Sele in RAW264.7 cells (Figures S3A and S3B).

ArticleVolume 45, Issue 9117877Open access Affiliations & Notes 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China 2National Institute of Biological Sciences, Beijing, 102206, China 3Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China 4Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research...