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Alfie M. Case on Muck Rack

Alfie M. Case

As seen in: Taylor & Francis Online
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AKR1C3 inhibitors and exploiters for the treatment and therapeutic monitoring of cancer: a patent review 2020-present

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By Melanie Smith, Alfie M. Case, Cole A. Mack
| Taylor & Francis Online
ABSTRACT INTRODUCTION Aldo-keto reductase 1C3 (AKR1C3) is a drug target for the treatment of various androgen dependent malignancies, including castration-resistant prostate canceras well as hematological cancers. The enzyme plays a key role in the conversion of androgen precursors into potent androgen receptor ligands and the conversion of prostaglandins from pro-differential to pro-proliferative, facilitating progression of these malignancies.
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