Alfred J. Simmons on Muck Rack

Alfred J. Simmons

As seen in: Frontiers in Immunology
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Articles

Identification, design, and in vivo proof of concept of a shared APC neoantigen delivered via a self-amplifying RNA containing virus-like nanoparticle for cancer vaccination

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By Anna S. Nikonova, Katherine Pniewski, Deepak C. Upreti, Maria Perez, María Pérez Verified, Alfred J. Simmons, Chloe D. Jonas, Satish Adhikari
| Frontiers in Immunology
Abstract Colorectal Cancer (CRC) accounts for the second highest number of cancer-related mortalities rate worldwide, and its incidence and mortality is expected to continue to increase in the coming years. Over 80% of CRC cases are caused by mutation in the Adenomatous Polyposis Coli (APC) gene, a tumor suppressor gene involved in the Wnt signaling pathway that prevents uncontrolled cell growth.
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