Ali Akbar Ashkarran

Morteza Mahmoudi Department of Radiology and Precision Health Program, Michigan State University, East Lansing, MI, 48824 USA Connors Center for Women's Health & Gender Biology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA Search for more papers by this author

Introduction Click to copy section linkSection link copied! Nanomedicine applies the nanotechnology concept to medicine, i.e., employing biocompatible nanoparticles (NPs) for controlled and/or targeted delivery of therapeutic (bio)molecules to desired tissues/organs, imaging, and disease diagnosis.

The protein/biomolecular corona is a dynamic biological layer that develops on the surface of nanoparticles when they are exposed to biological fluids including plasma. (1−4) This biological layer transforms nanoparticles by endowing them with a new identity that influences how they are recognized and interact within biological systems, thus defining their safety, biodistribution, diagnostic and therapeutic efficacy.