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Correction to: Nature https://doi.org/10.1038/s41586-026-10299-9 Published online 1 April 2026 In the version of this article initially published, there were typographical errors where in the Fig. 3e y-axis label and Fig.
Abstract Developing safe and effective pain medications is an ongoing challenge for human health. Agonists for the µ-opioid receptor (MOR) are essential pain medications, but their high intrinsic efficacy also induces adverse side effects, including respiratory depression, constipation, tolerance, dependence, withdrawal and addiction1,2,3,4,5,6,7.
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