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William Dunne

As seen in: Nature, Sunday Mirror, The Daily Mirror, Daily Star (UK), Liverpool Echo, Scottish Daily Record, Irish Mirror, Bristol Post, Belfast Live, Dublin Live and
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Author Correction: A µ-opioid receptor superagonist analgesic with minimal adverse effects

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By Juan Gomez, Juan Gómez, Emilya Ventriglia, Zachary Frangos, Agnieszka Sulima, Michael Robertson, Michael Sacco, Reece C. Budinich, Ilinca M. Giosan, Tongzhen Xie, Oscar Solis, Anna E. Tischer, Jennifer M. Bossert, Kiera E. Caldwell, Hannah Bonbrest, Amelie Essmann, Zelai M. Garçon-Poca, Shinbe Choi, Michael R. Noya, Feonil Limiac, Ali Arce, Grant C. Glatfelter, Margaret Robinson, Li Chen, Angelina A. Mullarkey, Dain R. Brademan, Garrett A Enten, William Dunne, Cesar Quiroz, César Camacho Quiroz, Ingrid Schoenborn, Chae Bin Lee, Rana Rais, Daniel P. Holt, Robert F. Dannals, Ruth Hüttenhain, Sergi Ferré, Eugene A. Kiyatkin, Jordi Bonaventura, Yavin Shaham, Venetia Zachariou, Michael Baumann Verified, Georgios Skiniotis, Michael Michaelides
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-026-10299-9 Published online 1 April 2026 In the version of this article initially published, there were typographical errors where in the Fig. 3e y-axis label and Fig.
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A µ-opioid receptor superagonist analgesic with minimal adverse effects

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By Juan Gomez Verified, Juan Gómez, Emilya Ventriglia, Zachary Frangos, Agnieszka Sulima, Michael Robertson, Michael Sacco, Reece C. Budinich, Ilinca M. Giosan, Tongzhen Xie, Oscar Solis, Anna E. Tischer, Jennifer M. Bossert, Kiera E. Caldwell, Hannah Bonbrest, Amelie Essmann, Zelai M. Garçon-Poca, Shinbe Choi, Michael R. Noya, Feonil Limiac, Ali Arce, Grant C. Glatfelter, Margaret Robinson, LI YI CHEN, Angelina A. Mullarkey, Dain R. Brademan, Garrett A Enten, William Dunne, Cesar Quiroz, César Camacho Quiroz, Ingrid Schoenborn, Chae Bin Lee, Rana Rais, Daniel P. Holt, Robert F. Dannals, Ruth Hüttenhain, Sergi Ferré, Eugene A. Kiyatkin, Jordi Bonaventura, Yavin Shaham, Venetia Zachariou, Michael Baumann Verified, Georgios Skiniotis, Michael Michaelides
| Nature Verified
Abstract Developing safe and effective pain medications is an ongoing challenge for human health. Agonists for the µ-opioid receptor (MOR) are essential pain medications, but their high intrinsic efficacy also induces adverse side effects, including respiratory depression, constipation, tolerance, dependence, withdrawal and addiction1,2,3,4,5,6,7.
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Cocaine chemogenetics blunts drug-seeking by synthetic physiology - Nature

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By Christopher J. Magnus, Jordi Bonaventura, Oscar Solis, Marjorie R Levinstein, William Dunne, Michael Michaelides
| Nature Verified
Abstract Chemical feedback is ubiquitous in physiology but is challenging to study without perturbing basal functions. One example is addictive drugs, which elicit a positive-feedback cycle of drug-seeking and ingestion by acting on the brain to increase dopamine signalling1,2,3. However, interfering with this process by altering basal dopamine also adversely affects learning, movement, attention and wakefulness4.
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