Ali Ranjbaran

Keywords single cell chromatin accessibility transcription factor binding sites expression quantitative trait loci transcription factor gene expression dynamics gene expression variability fine-mapping functional genomics asthma Get full text access Log in, subscribe or purchase for full access. References 1. Jenkins, C.R. ∙ Bateman, E.D. ∙ Sears, M.R. ... What have we learnt about asthma control from trials of budesonide/formoterol as maintenance and reliever? Respirology. 2020; 25:804-815 2.

Abstract Genotype × environment interactions (GxE) have long been recognized as a key mechanism underlying human phenotypic variation. Technological developments over the past 15 years have dramatically expanded our appreciation of the role of GxE in both gene regulation and complex traits. The richness and complexity of these datasets also required parallel efforts to develop robust and sensitive statistical and computational approaches.

Psychosocial experiences affect children's development and health. Urban environments in particular expose children to chronic stress, which impacts the HPA axis and leads to an altered glucocorticoid response. Because glucocorticoids have a major anti-inflammatory action, negative psychosocial experiences may be associated with immunological disorders, including asthma.