Alice Galli

1 Introduction Striatal dopaminergic deficit is a supportive biomarker for PD diagnosis [1]. Dopamine transporter single-photon emission computed tomography (DAT-SPECT) is the main neuroimaging technique used in both clinical research and practice to assess the presence and the degree of nigrostriatal dopaminergic dysfunction [2].

Introduction Identifying in vivo markers that reflect risk for phenoconversion to clinically evident alpha-synucleinopathies remains an unmet need. Alpha-synucleinopathies include a spectrum of neurodegenerative disorders characterized by neuronal loss caused by the aggregation of misfolded α-synuclein protein leading to dopaminergic deficits.