Alice Mac Kain on Muck Rack

Alice Mac Kain

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Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen - Nature Communications

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By Artem Baidaliuk, Flora Donati, Thomas Vallet, Alexandra Hardy, Maxime Chazal, Françoise Porrot, Molly Ohainle, Jared Carlson-Stevermer, Kevin Holden Verified, Etienne Simon-Loriere, Timothée Bruel, Olivier Schwartz, Nolwenn Jouvenet, Ferdinand Roesch, Alice Mac Kain, Nathalie Arhel, Quang Dinh Tran, Gert Zimmer, Sébastien Nisole
| Nature Verified
Abstract Interferon restricts SARS-CoV-2 replication in cell culture, but only a handful of Interferon Stimulated Genes with antiviral activity against SARS-CoV-2 have been identified. Here, we describe a functional CRISPR/Cas9 screen aiming at identifying SARS-CoV-2 restriction factors. We identify DAXX, a scaffold protein residing in PML nuclear bodies known to limit the replication of DNA viruses and retroviruses, as a potent inhibitor of SARS-CoV-2 and SARS-CoV replication in human cells.
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