Alina PS Pang on Muck Rack

Alina PS Pang

As seen in: Nature
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Articles

Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy

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By Michael Corley, Varun B. Dwaraka, Alina PS Pang, Danielle Labbato, Ryan Smith, Allison Ross Eckard, Grace A McComsey
| Nature
Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists have attracted interest as gerotherapeutics, yet clinical-trial evidence for their effects on biological aging is lacking. We report a post hoc exploratory epigenetic age analysis of a 32-week, randomized, double-blind, placebo-controlled phase 2b trial (NCT04019197) of semaglutide in adults with human immunodeficiency virus (HIV)-associated lipohypertrophy (semaglutide n = 45; placebo n = 39).
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Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states

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By Lishomwa C. Ndhlovu, Matthew L. Bendall, Varun Bhamidipati Dwaraka, Alina PS Pang
| biorxiv.org
Abstract Human endogenous retroviruses (HERVs), the remnants of ancient viral infections embedded within the human genome, and long interspersed nuclear elements 1 (LINE-1), a class of autonomous retrotransposons, are silenced by host epigenetic mechanisms including DNA methylation. The resurrection of particular retroelements has been linked to biological aging.
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