Aline Araujo Zuma

Abstract Based on the in vitro trypanocidal efficacy of previously synthesized N-aryl-1,10-phenanthroline-2-amines (Phen1-20) (aryl = R-phenyl, 1- or 2-naphthyl), we explored the potential interactions of these derivatives as ligands of our comparative model of T. cruzi GP63 (TcGP63). This surface metalloprotease plays a crucial role in parasite adhesion to host cells and aids in cell invasion during T. cruzi infection in Chagas disease.

CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES , , , , & (2021) First report of the presence of Anaplasma marginale in different tissues of the stable-fly Stomoxys calcitrans (Linnaeus, 1758) in Rio de Janeiro state, Brazil. Veterinary Parasitology: Regional Studies and Reports, 23, 100515. Available from: https://doi.org/10.1016/j.vprsr.2020.100515 & (2018) Saliva of hematophagous insects: a multifaceted toolkit.