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Abstract Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in serum samples of 636 PD and 253 non-PD participants recruited from Central California. We conducted an initial discovery metabolome-wide association and pathway enrichment analysis.

RESEARCH ARTICLE Cynthia D.J. Kusters MD, PhD, Corresponding Author ckusters@ucla.edu orcid.org/0000-0001-8099-9026 Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA Correspondence to: Dr. Cynthia D.J. Kusters, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, 695 Charles E.

Abstract Objective We examine the hypothesized overlap of genetic architecture for Alzheimer disease (AD), schizophrenia (SZ), and Parkinson disease (PD) through the use of polygenic risk scores (PRSs) with the occurrence of hallucinations in PD.